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ctgf最新视觉报道_ctgf 瘢痕(2024年11月全程跟踪)

内容来源：卡姆驱动平台所属栏目：热点更新日期：2024-11-28

ctgf

YAP-TEAD的乳酸化促进Hippo通路靶基因表达第一步，YAP-TEAD的乳酸化促进Hippo通路靶基因的表达质核分离分析显示，乳酸强烈促进WT YAP的核定位，但不促进其K90R突变体的核定位，表明乳酸诱导的YAP激活需要K90乳酸化（图1e）。Co-IP实验发现乳酸增强TEAD1与WT YAP的相互作用，而不是其K90R突变体（图1f）。此外，乳酸增加了过表达WT YAP的细胞中CTGF和CYR61的mRNA水平，但过表达YAP K90R突变体的影响较小（图1g）。ChIP实验显示，乳酸处理增强了WT TEAD1在CTGF和CYR61启动子上的占据，而不是其K108R突变体（图1h）。表明细胞内乳酸促进了YAP-TEAD1的乳酸化水平和转录活性。第二步，YAP-TEAD1的乳酸化和泛素化之间的相互作用核质分离实验显示，大部分乳酸化的YAP和TEAD1定位在细胞核内，而s127磷酸化的YAP或泛素化的YAP和TEAD1主要分布在细胞质内（图1i-j）。乳酸处理降低了YAP-TEAD1的泛素化水平（图1k），促进了AARS1的核定位及其与YAP-TEAD的相互作用。此外，WT AARS1促进了YAP-TEAD1的乳酸化，但LS突变体没有（图1l）。表明YAP的乳酸化破坏了其易位进入细胞质后进行的泛素化。全文：【《JCI》解读：肿瘤乳酸化修饰与泛素化修饰对抗！丙烯酰tRNA合成酶AARS1乳酸化修饰YAP复合体促进信号传导】。如有相关科研问题，欢迎留言探讨。 #科研#⠂ #coip实验#⠂ #chip实验#⠂ #乳酸化#

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