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SOX9最新视觉报道_sox9抗体是表面还是胞内(2024年12月全程跟踪)

内容来源：卡姆驱动平台所属栏目：热点更新日期：2024-12-01

SOX9

研究发现：保护毛囊干细胞免受病毒侵扰有利于促进毛发再生和修复！近日，美国德州大学MD安德森癌症中心的葛烨晶教授团队在《Cell》期刊上发表了一项开创性的研究，揭示了毛囊干细胞中的关键分子——SETDB1——如何在毛发再生中扮演重要角色。这种叫SETDB1的组蛋白甲基转移酶对毛囊的生死存亡有着至关重要的影响。SETDB1就像毛囊的守护神，一直在努力抑制毛囊干细胞中的“坏蛋”——内源性逆转录病毒（ERVs）。如果SETDB1被削弱或缺失，ERVs就会被释放出来，在毛囊细胞中制造混乱。也就是说，SETDB1缺失的毛囊干细胞就像拆除了防火墙的电脑，很容易被病毒入侵，变得老化、凋亡，甚至导致毛囊干细胞“弹尽粮绝”，无法再生出新的毛发。研究表明，DNA羟甲基化与毛囊干细胞的抗病毒反应密切相关，ERV的活跃会导致毛囊的组织再生能力受损。本研究结果显示，ERV抑制对于保持干细胞健康状态和维持毛发再生具有重要作用。 “毛囊干细胞中的一些关键转录因子，保护着毛囊干细胞，防止它们过早衰老和脱落。例如NFATC1和FOXC1，就像一支配合默契的“超级英雄组合”，主要负责维持细胞的“休眠状态”安全，而Sox9和Nfib/x则在干细胞受损后帮助它们进行修复和再生。研究结果说明，ERV抑制机制不仅在细胞活跃时发挥作用，在细胞进入修复模式时也同样重要。总的来说，“潜伏”的ERVs在毛囊干细胞中充当着“麻烦制造者”的角色。通过SETDB1及相关转录因子的协同作用，这些ERVs被抑制，毛囊干细胞才能健康运行，完成毛发的再生。如果ERVs过度活跃，毛囊干细胞就会加速衰退，甚至进入不可逆的脱发阶段。如果我们能找到一种直接作用于毛囊干细胞的抗病毒药物，将可能在脱发治疗领域带来革命性的突破。

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