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CD33最新视觉报道_cd33单抗(2024年11月全程跟踪)

内容来源：卡姆驱动平台所属栏目：热点更新日期：2024-11-28

CD33

双特异性T细胞衔接器（BiTE)的抗体结构是由两个单链可变区通过灵活的肽链链接而成，一侧结合域可识别肿瘤表达抗原（CD19、CD33、BCMA），另一侧通常识别T细胞表面的CD3，从而可以衔接T细胞和肿瘤靶细胞，引起T细胞活化并杀伤肿瘤靶细胞。当BiTE分子与细胞毒性T细胞和肿瘤细胞结合后，T细胞即开始增殖，通过增加效应细胞的数量来增强BiTE的治疗效力，增强对肿瘤细胞的裂解作用。贝林妥欧单抗（CD3✖️CD19 BiTE）是不欠唯一获批用于治疗成人及儿童急性淋巴细胞白血病的CD3✖️CD19双抗。（图片来自网络）

百利天恒：BL-M11D1（CD33-ADC）用于治疗复发或难治性急性髓系白血病患者的I期临床试验申请获得FDA许可

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