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fasn最新视觉报道_fasnion是什么品牌(2024年11月全程跟踪)

内容来源：卡姆驱动平台所属栏目：热点更新日期：2024-11-29

fasn

乳酸化与能量代谢：深入解析糖酵解的奥秘 𐟌Ÿ 糖酵解与乳酸化的关系 𐟌Ÿ 糖酵解过程中产生的乳酸化现象与能量代谢密切相关。中国农业大学食品科学与营养工程学院的黄昆仑教授和首都医科大学附属北京地坛医院的贺晓云副教授在国际期刊《肝脏病学》（Hepatology）上发表了一篇题为“Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease”的研究论文。 𐟔 论文摘要 𐟔 非酒精性脂肪肝病（NAFLD）已成为威胁人类肝脏健康的重要疾病。在NAFLD的发病机制中，从头脂肪合成（DNL）的异常激活被认为是肝脏脂质积累的关键因素。因此，通过调控DNL来减轻肝脏脂质沉积和脂肪变性是NAFLD治疗领域的研究热点。 𐟒ᠧ ”究发现 𐟒ኧ𚿧𒒤𝓤𘙩…𘨽𝤽“（MPC）是一种重要的功能性载体蛋白，负责将糖酵解产生的丙酮酸运送到线粒体中进行下游代谢。研究发现，MPC1的表达与非酒精性脂肪肝患者的肝脏脂质沉积呈正相关。MPC1敲除可以有效减轻高脂饮食诱导的肝脏脂质积累。进一步研究表明，MPC1通过调节肝细胞中的乳酸水平影响脂肪酸合成酶（FASN）的乳酸化修饰并抑制FASN活性，从而下调肝细胞的从头脂肪生成，减缓非酒精性脂肪肝病的发展。 𐟓Š 研究思路 𐟓Š 研究者通过代谢组、蛋白组、转录组等手段检测能量代谢相关代谢产物、限速酶表达水平，打通表型与分子机制，深入理解乳酸化与代谢调控的关系。这些研究为疾病机制、药物靶点发现、治疗方案提供了新的视角。 𐟓š 总结 𐟓š 乳酸作为糖酵解过程中的一种中间产物，在能量代谢中扮演着重要角色。越来越多的研究表明，乳酸化不仅影响蛋白的修饰水平，还与多种代谢途径密切相关。通过综合运用代谢组学、蛋白组学和转录组学等方法，研究者可以更深入地理解乳酸化与代谢调控的关系，为疾病机制、药物靶点发现、治疗方案提供新的思路。

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